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BLAST Search

 

Basic Local Alignment Search Tool [1] is a widely used bioinformatics algorithm tool that allows the comparison of primary biological sequences (amino acids of proteins and/or nucleotides of DNA sequences). This comparison is done against a library or database of sequences. It is faster than other search tools like FASTA [2] because it utilizes approximate match sequencing and searches for more prominent arrangements in sequences rather than an exact match.

 

Human Isoform a

 

Human Isoform b

 

Human Isoform c

 

Cattle

 

Naked-Mole Rat

References

1. Altschul, S.F., Gish, W., Miller, W., Myers, E.W. & Lipman, D.J. (1990) Basic local alignment search tool. Journal of Molecula Biology 215:403-410. 

2. Pearson, W.R. (1991) Searching protein sequence libraries: comparison of the sensitivity and selectivity of the Smith-Waterman and FASTA algorithms. Genomics 11(3):635-50 

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