top of page
Representative Proteins

 

Protein of interest

Pleckstrin homology-like domain family B member 2 isoform a /isoform 1 [Homo Sapiens]

 

  • Organism: Homo Sapiens (Humans)

 

  • Length: 1,253 amino acids

 

  • Mass (Da): 142,158

 

  • Gene: PHLDB2

 

  • Mutagenesis: At position 1162-1163: change of KR (Lycine-Arginine)-->AA(Alanine-Alanine) which results in the loss of  binding to PtdIns(3,4,5)P3 (Phosphatidylinositol (3,4,5)-trisphosphate).

 

  • Proteosome: Expressed by Chromosome 3

 

  • Function:  Involved in assembly of postsynaptic apparatus. Also, may play a role in AChR aggregation in the postsynaptic membrane.

 

  • Subcellular Location:  High levels of PtdIns(3,4,5)P3 induce translocation to the plasma membrane. Low levels of PtdIns(3,4,5)P3 induce translocation to vesicular compartments.

 

 

 

Interestingly, it has 3 isoforms in humans as a result of alternative splicing. 

Alternative splicing is a process in which a single gene procudes multiple similar proteins due to the variation in incorporated exons; in the case of our pleckstrin homology-like domain family B member 2, 3 isoforms (a,b,c/1,2,3).

Click here to learn more about alternative splicing.

 

Relate proteins

Pleckstrin homology-like domain family B member 2 isoform 2 [Homo sapiens]

 

  • Length: 1,210 amino acids

 

  • Mass (Da): 136,886

 

  • How does it differ from previous isoform a/1?  Amino acid deletions at position 668-710

 

 

Pleckstrin homology-like domain family B member 2 isoform 3 [Homo sapiens]

 

  • Length: 1,237 amino acids

 

  • Mass (Da): 138,974

 

  • How does it differ from previous isoform a/1?

At position 1-1: M→ MEEEDTKREVPKEDGVGDVQHFDSSKIM

&

Amino acid deletion at position 668-710

(Click here to see amino-acid single letter code table)

 

 

 

Pleckstrin homology-like domain family B member 2 [Bos taurus]→ cattle

 

  • Length: 189 amino acids

 

  • Mass (Da): 21,387

 

 

 

Pleckstrin homology-like domain family B member 2 [Fukomys damarensis]→ Damaraland mole-rat

 

  • Length: 221 amino acids

 

  • Mass (Da): 24,488

 

 

 

Pleckstrin-like protein domain family B member 2 [Heterocephalus glaber]→ Naked mole rat

 

  • Length: 127 amino acids

 

  • Mass (Da): 14,064

 

  • Function: Metal Ion binding, interacts selectively and non-

    covalently with any metal ion

 

 

 

 

 

 

bottom of page